Strus was 8 of 12 from the field including three 3-pointers for the Blue Demons (3-4). Marin Maric and Tre'Darius McCallum added 17 points apiece, Eli Cain had 15 points and seven rebounds and Brandon Cyrus chipped in 12 points off the bench.
DePaul never trailed, averaging 57.6 percent shooting from the field compared to 43 percent for Youngstown State.
Strus scored 11 points in the first half, making three 3-pointers and a dunk, to help lift DePaul to a 47-32 advantage at the break.
The Blue Demons extended it to 55-34 on a Cain 3-pointer early in the second half and cruised from there.
Braun Hartfield scored 23 points on 7-of-12 shooting for the Penguins (2-7) who are on a five-game skid.
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