Nate Navigato played all 40 minutes and scored 17 points with five 3-pointers for Toledo (4-3). Marreon Jackson added 14 points and Luke Knapke chipped in 12.
Divonte Lumpkin scored 27 points and Demontrae Jefferson had 25 for Texas Southern (0-8).
Jefferson made four free throws and Robert Lewis added another during a 5-0 spurt that gave Texas Southern a 64-62 lead with 2:16 to play. Fletcher made a layup and a jumper and the Rockets regained the lead 66-64. Texas Southern pulled within 68-67 on Jefferson's 3-pointer.
Jackson split a pair of free throws with eight seconds left, and Texas Southern's Brian Carey missed a 3-pointer to end it.
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